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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MMP14
All Species:
9.09
Human Site:
Y141
Identified Species:
22.22
UniProt:
P50281
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P50281
NP_004986.1
582
65884
Y141
K
V
G
E
Y
A
T
Y
E
A
I
R
K
A
F
Chimpanzee
Pan troglodytes
XP_001157686
582
65864
Y141
K
V
G
E
Y
A
T
Y
E
A
I
R
K
A
F
Rhesus Macaque
Macaca mulatta
XP_001100232
582
65866
Y141
K
V
G
E
Y
A
T
Y
E
A
I
R
K
A
F
Dog
Lupus familis
XP_856947
582
65834
F140
K
V
G
E
Y
A
T
F
E
A
I
R
K
A
F
Cat
Felis silvestris
Mouse
Mus musculus
P53690
582
65917
F141
K
V
G
E
Y
A
T
F
E
A
I
R
K
A
F
Rat
Rattus norvegicus
Q10739
582
66062
F141
K
V
G
E
Y
A
T
F
E
A
I
R
K
A
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506645
616
70261
R158
K
V
G
D
A
E
T
R
K
A
I
R
R
A
F
Chicken
Gallus gallus
NP_990528
608
69394
R149
K
V
G
D
A
E
T
R
K
A
I
R
R
A
F
Frog
Xenopus laevis
Q10835
469
53622
L86
G
K
L
N
E
D
T
L
D
I
M
K
Q
P
R
Zebra Danio
Brachydanio rerio
NP_919395
621
71111
F134
K
V
G
E
Y
E
T
F
E
A
I
R
K
A
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.1
97
N.A.
96.5
96.9
N.A.
53
52.6
31.9
65.2
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
100
99.4
98.1
N.A.
97.7
98.4
N.A.
70.4
69.7
45.1
77.9
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
60
60
6.6
86.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
80
80
33.3
93.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
20
60
0
0
0
90
0
0
0
90
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
20
0
10
0
0
10
0
0
0
0
0
0
% D
% Glu:
0
0
0
70
10
30
0
0
70
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
40
0
0
0
0
0
0
90
% F
% Gly:
10
0
90
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
10
90
0
0
0
0
% I
% Lys:
90
10
0
0
0
0
0
0
20
0
0
10
70
0
0
% K
% Leu:
0
0
10
0
0
0
0
10
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% M
% Asn:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% Q
% Arg:
0
0
0
0
0
0
0
20
0
0
0
90
20
0
10
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
100
0
0
0
0
0
0
0
0
% T
% Val:
0
90
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
70
0
0
30
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _